Dimethylamine → 2-(2-(2-(Dimethylamino)ethoxy)ethoxy)ethanol

Participants

Role	Name	HCID	Charge
Reactant	Dimethylamine	HCID 674	—
Reactant	2-(2-(2-Chloroethoxy)ethoxy)ethanol	HCID 78871	—
Product	2-(2-(2-(Dimethylamino)ethoxy)ethoxy)ethanol	HCID 10845034	—

Reaction Steps

Commercial Cl(CH2CH2O)3H (abb. ClE3H) (2.0 mole) and dimethylamine (20.0 mole) were mixed in a flask (3.0 l) fitted with a condenser and stirred (RT) for 30 hours. TLC (Si-gel) examination showed the complete consumption of the ClE3H. Excess dimethylamine was removed by two consecutive evaporations under reduced pressure. The residual material was reconstituted in CHCl3, dried (MgSO4), filtered and evaporated to dryness to produce the product, 8-dimethylamino-3,6-dioxaoctanol.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04263281
Source dataset	uspto-grants-1981_04
ORD ID	ord-640529c8258d4e74a8dd8c70eedc4121
Source note	uspto-grants-1981_04