Dimethylamine → 2-Carboxy-4-methyl-2-[(dimethylamino)methyl]pentanoic acid

Participants

Reaction Conditions

Reaction Steps

2-Carboxy-4-methylpentanoic acid (67 g) is suspended in 400 ml of water and cooled to 5° C. Aqueous 40% dimethylamine (50 g) is added to the suspension followed by aqueous 37% formaldehyde (35.7 g). The resulting solution is stirred for about 16 hours and solid product is filtered and dried in vacuo to yield 57.3 g of the title compound, melting point 134°-137° C. with carbon dioxide and dimethylamine given off.

Provenance & Evidence