HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 1,2,3,6-Tetrahydro-3-methyl-4-pyrrolidinylpyridine-1-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | Ethyl 3-methyl-4-oxopiperidine-1-carboxylate | HCID 15075657 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 1,2,3,6-Tetrahydro-3-methyl-4-pyrrolidinylpyridine-1-carboxylic acid ethyl ester | HCID 57259460 | — |
Reaction Steps
A mixture of 92.2 g of 1-carbethoxy-3-methyl-4-piperidone and 53.5 g of pyrrolidine in 1.0 liter of benzene is heated to the boil at reflux for 2 hours and the resulting water is continuously removed azeotropically. The reaction mixture is concentrated and the crude 1,2,3,6-tetrahydro-3-methyl-4-pyrrolidinylpyridine-1-carboxylic acid ethyl ester, obtained as an oil, is used as such for the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04263298 |
| Source dataset | uspto-grants-1981_04 |
| ORD ID | ord-f2a9b5ec26064b169af90b9d44521f4d |
| Source note | uspto-grants-1981_04 |