HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acefylline → N-[2-(4-Cyanophenyl)-ethyl]-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acefylline | HCID 69550 | — |
| Reactant | 4-(2-Aminoethyl)benzonitrile | HCID 21912525 | — |
| Product | N-[2-(4-Cyanophenyl)-ethyl]-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)acetamide | HCID 59205118 | 21.2% |
Reaction Steps
Compound 409 (93 mg, 21%) was prepared from 101 (300 mg, 1.3 mmol) and 115 (175 mg, 1.2 mmol) according to General Procedure B. MS (APCI): m/z 367 [M+H]+. Anal. Calcd. for C18H18N6O3.0.04EtOAc.0.1H2O: C, 58.68; H, 5.02; N, 22.61. Found: C, 58.75; H, 5.01; N, 22.46.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08541423B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-043c58e87eac4d25821711ff7f9377e9 |
| Source note | uspto-grants-2013_09 |