3-Bromo-1-propanol → HCID 13097926, compound

HRID 444223Notes

Reaction equation

[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:15][CH2:16][CH2:17][OH:18]>>[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([CH2:15][CH2:16][CH2:17][OH:18])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 123083-Bromo-1-propanol

HCID 759941-Benzylpiperazine

Product 1

HCID 13097926HCID 13097926, compound

Procedure

Alkylation of 1-benzylpiperazine (16 g, 0.091 mole) with 3-bromopropan-1-ol (13.88 g; 0.01 mole) as described in Example 1(c) gave, after chromatography, 12.9 g (61%) of the product as a colourless oil. νmax (film) 3300, 2920, 2800, 1595 cm-1 ; (Found; C, 69.41; H, 9.60; N, 11.75; C14H22N2O.O.5H2O requires; C, 69.10; H, 9.52; N, 11.51%).

Workup

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Sources & evidence

ORD record: ord-e632ae83cd7647b7be4a02d4df81452a
Source dataset: uspto-grants-1981_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04263299

Reaction notes

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