Tetrafluoro-m-phenylenediamine dihydrochloride → HCID 13408417, compound

HRID 444224Notes

Reaction equation

HRID 444224 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][OH:17])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]([O:20][C:21]1[C:30]2[C:25](=[CH:26][C:27](O)=[CH:28][CH:29]=2)[O:24][C:23](=[O:32])[CH:22]=1)[CH3:19].C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>C(O)C>[CH2:1]([N:8]1[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][CH2:16][O:17][C:27]2[CH:26]=[C:25]3[C:30]([C:21]([O:20][CH2:18][CH3:19])=[CH:22][C:23](=[O:32])[O:24]3)=[CH:29][CH:28]=2)[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 5688257HCID 5688257, compoundHCID 13097926HCID 13097926, compound

Product 1

HCID 13408417HCID 13408417, compoundYield 61.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Condensation of 1-benzyl-4-(3-hydroxypropyl)piperazine (12.5 g) with 4-ethoxy-7-hydroxycoumarin (11 g) as described in Example 4(b) gave 13.8 g (52%) of the title compound as its dihydrochloride of m.p. (ethanol) 240°-241° C.; (Found; C, 59.89; H, 6.47; N, 5.68; Cl, 14.44; C25H30N2O4.2HCl requires; C, 60.60; H, 6.51; N, 5.66; Cl, 14.31%).

Sources & evidence

ORD record
ord-9e90986d93664d38aebbcd929ba7077f
Source dataset
uspto-grants-1981_04
Patent number
US04263299

Reaction notes

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