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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 444276Generated: October 27, 2026

3-Carbamoyloxymethyl-7-amino-3-cephem-4-carboxylic acid → 7-[2-Methoxyimino-2-(1,2,3-thiadiazol-4-yl)acetamido]-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid

https://huagongshe.com/reaction/444276

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Carbamoyloxymethyl-7-amino-3-cephem-4-carboxylic acidHCID 12784759—
Reactant2-Methoxyimino-2-(1,2,3-thiadiazol-4-yl)acetic acidHCID 54347340—
Product7-[2-Methoxyimino-2-(1,2,3-thiadiazol-4-yl)acetamido]-3-carbamoyloxymethyl-3-cephem-4-carboxylic acidHCID 13171219145.6%

Reaction Steps

2-Methoxyimino-2-(1,2,3-thiadiazol-4-yl)acetic acid (syn isomer)(0.65 g) and 7-amino-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid (0.96 g) were reacted according to similar manners to those of Examples 12 and 15 to give 7-[2-methoxyimino-2-(1,2,3-thiadiazol-4-yl)acetamido]-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid (syn isomer) (0.7 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04263291
Source datasetuspto-grants-1981_04
ORD IDord-d333b7d02df84db490619ebeb0134ae3
Source noteuspto-grants-1981_04