Sulfuric Acid → 5,6-Bis(p-anisyl)-2,3-dihydroimidazo[2,1-b]thiazole sulfate

HRID 444287Notes

Reaction equation

HRID 444287 reaction equation
[CH2:1]([C:10]1[N:17]2[C:13]([S:14][CH2:15][CH2:16]2)=[N:12][C:11]=1[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=1)[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.C(Cl)Cl.[S:30](=[O:34])(=[O:33])([OH:32])[OH:31]>C(O)C>[S:30]([OH:34])([OH:33])(=[O:32])=[O:31].[CH2:1]([C:10]1[N:17]2[C:13]([S:14][CH2:15][CH2:16]2)=[N:12][C:11]=1[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=1)[C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 6344DichloromethaneHCID 571019865,6-Bis(p-anisyl)-2,3-dihydroimidazo[2,1-b]thiazole

Product 1

HCID 705745685,6-Bis(p-anisyl)-2,3-dihydroimidazo[2,1-b]thiazole sulfate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 5,6-bis(p-anisyl)-2,3-dihydroimidazo[2,1-b]thiazole in 3 parts methylene chloride and 1 part absolute ethanol is added a solution containing an equimolar amount of sulfuric acid dissolved in absolute ethanol. The mixture is stripped of solvent and the residue recrystallized from absolute ethanol-ether containing a small amount of added sulfuric acid to give 5,6-bis(p-anisyl)-2,3-dihydroimidazo[2,1-b]thiazole sulfate, m.p. 268°-273° C. (dec.).

Workup

  1. customthe residue recrystallized from absolute ethanol-ether containing a small amount of added sulfuric acid

Sources & evidence

ORD record
ord-b7479f165ad2423198dc276442b0b277
Source dataset
uspto-grants-1981_04
Patent number
US04263311

Reaction notes

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