1,2-Dibromoethane → HCID 13526423, compound

Participants

Reaction Steps

A slurry of 3.5 g. (0.01 mole) of 4,5-bis(3,4-methylenedioxyphenyl)-2-mercaptoimidazole, 2.0 g. (0.01 mole) of 1,2-dibromoethane and 2 g. (0.014 mole) of potassium carbonate in dimethylformamide (45 ml.) was refluxed for 2.5 hours and then poured into 500 ml. of ice water. The precipitate was collected, washed with water and dried. Chromatography (alumina/chloroform) gave 5,6-bis(3,4-methylenedioxyphenyl)-2,3-dihyroimidazo[2,1-b]thiazole. This was dissolved in methanol and treated with aqueous hydrobromic acid. The solvent was removed and the residue recrystallized from methanol to give 5,6-bis(3,4-methylenedioxyphenyl)-2,3-dihydroimidazo[2,1-b]thiazole hydrobromide, m.p. 278°-280° C.

Provenance & Evidence