HCID 20506962, compound → HCID 13134778, compound

Participants

Reaction Conditions

Reaction Steps

To 59 mg of 2-(4-carbamoylmethylphenoxy)phenylacetic acid was added 1.8 g of polyphosphoric acid, and the mixture was stirred under a dry atmosphere at 100° C. for 50 minutes. After being cooled, the resulting mixture was dissolved in water and then extracted with ethyl acetate. The extract was washed with a 1% sodium hydroxide solution and then with a saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was distilled off to obtain a residue, which was recrystallized from acetone/n-hexane to give 45 mg (yield: 76%) of (10,11-dihydro-11-oxo dibenzo[b,f]oxepin-2-yl)-acetamide as light yellow crystals having a melting point of 151.5°-154° C.

Provenance & Evidence