Hydrazine hydrate (1:1) → 4-Phenyl-1-(2H)-phthalazinone

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-benzoyl-benzoic acid N′,N′-dimethyl-hydrazide 17 (1 mmol) and H2NNH2.H2O (18 mmol) was stirred for 2 hrs at 100° C. After the excess hydrazine was removed under reduced pressure, the crude product was purified by chromatography on silica gel ((1:2) EtOAc:hexane) to give the desired product in 95% yield.

Provenance & Evidence