Ethanol → HCID 12878956, compound

Participants

Reaction Steps

A mixture of 32 g of o-aminothiophenol, 70.7 g of p-chlorobenzalmalonate and 1.4 g of pyridine hydrochloride was heated at about 180° C. until no further ethanol was distilled out (for about 4 hours). After allowing the reaction mixture to cool, a mixture of benzene-petroleum ether was added to the reaction mixture which was then thoroughly stirred and filtered. The resulting filter cake was recrystallized from chloroform-petroleum ether to obtain 54.5 g of 2-(p-chlorophenyl)-2,3-dihydro-3-ethoxycarbonyl-1,5-benzothiazepin-4(5H)-one as colorless needles having a melting point of 206° C.

Provenance & Evidence