2-Aminothiophenol → HCID 12878961, compound

Participants

Reaction Steps

A mixture of 32 g of o-aminothiophenol, 65.6 g of p-methylbenzalmalonate and 1.4 g of triethylamine hydrochloride was heated at about 180° C. until no further ethanol was distilled out (for about 3 hours). The resulting reaction mixture was worked up in the same manner as described in Reference Example 2 (a) and the crystals thus obtained was recrystallized from chloroform-petroleum ether to obtain 34 g of 2,3-dihydro-3-ethoxycarbonyl-2-(p-tolyl)-1,5-benzothiazepin-4(5H)-one as light yellow needles having a melting point of 185° C.

Provenance & Evidence