2-Aminothiophenol → HCID 12878966, compound

Participants

Reaction Steps

A mixture of 32 g of o-aminothiophenol, 69.6 g of ethyl p-methoxybenzalmalonate and 1.6 g of triethylamine hydrochloride was heated at about 180° C. until no further ethanol was distilled out (for about 4 hours). The resulting mixture was then worked up in the same manner as described in Reference Example 2 (a) and the crystals thus obtained were recrystallized from chloroform-petroleum ether to obtain 25 g of 2,3-dihydro-3-ethoxycarbonyl-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one as colorless needles having a melting point of 192° C.

Provenance & Evidence