Dichloromethane → HCID 23463661, compound

Participants

Reaction Steps

To a solution of 2',5-dichloro-2-(5-carbobenzoxyaminomethyl-3-mercaptomethyl-1,2,4-triazol-4-yl)-benzophenone (0.5 g), triethylamine (0.5 ml) and methylene chloride (10 ml) is added a solution of ethyl chlorocarbonate (0.5 ml) in tetrahydrofuran (8 ml) at 15° C. with stirring. The reaction mixture is stirred for 1 hour and poured into water. The organic layer is washed with water, dried over sodium sulfate and evaporated to remove the solvent. The residual oily material is chromatographed on a column of silica gel, whereby 2',5-dichloro-2-(5-carbobenzoxyaminomethyl-3-ethoxycarbonylthiomethyl-1,2,4-triazol-4-yl)benzophenone (0.5 g) is obtained as a colorless oil.

Provenance & Evidence