反应详情

温度

60 °C

A solution of 22 (12 mmol) in tetrachloroethane was added to the suspension of AlCl3 (36 mmol) in tetrachloroethane (50 ml). The resulting mixture was heated to 60° C. for 1.5 hrs. The reaction mixture was quenched by addition of 1 M HCl (50 ml). Then, the mixture was basified by addition of NaOH (1M aqueous solution), the resulted layers were separated, and the aqueous layer was acidified by HCl (aqueous solution). This aqueous phase was extracted with CH2Cl2, dried over MgSO4 and finally the solvents were removed under reduced pressure, to give 35% yield of the desired product.

1. customThe reaction mixture was quenched by addition of 1 M HCl (50 ml)
2. additionThen, the mixture was basified by addition of NaOH (1M aqueous solution)
3. customthe resulted layers were separated
4. extractionThis aqueous phase was extracted with CH2Cl2
5. dry with materialdried over MgSO4
6. customfinally the solvents were removed under reduced pressure