1,3-Diethyl 2-oxopropanedioate → HCID 13014080, compound

HRID 444439Notes

Reaction equation

HRID 444439 reaction equation
[I:1][C:2]1[C:7]([I:8])=[CH:6][C:5]([NH2:9])=[C:4]([NH2:10])[CH:3]=1.O=[C:12]([C:18](OCC)=[O:19])[C:13]([O:15][CH2:16][CH3:17])=[O:14]>C(O)C>[I:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][C:7]=1[I:8])[N:9]=[C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:18](=[O:19])[NH:10]2

Participants

4

Reactant 2

HCID 691051,3-Diethyl 2-oxopropanedioateHCID 116101834,5-DIIODO-BENZENE-1,2-DIAMINE

Product 1

HCID 13014080HCID 13014080, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution was prepared from 0.9 g. of 4,5-diiodo-o-phenylenediamine and 25 ml. of ethanol. Five grams of diethyl ketomalonate were added and the resulting mixture was heated to refluxing temperature with stirring overnight. The reaction mixture was then cooled. Ethyl 6,7-diiodo-3,4-dihydro-3-oxo-2-quinoxaline carboxylate formed in the above reaction precipitated and was collected by filtration; yield=0.8 g.; mp=275°-276° C.

Workup

  1. customA solution was prepared from 0.9 g
  2. temperaturethe resulting mixture was heated
  3. temperatureto refluxing temperature
  4. temperatureThe reaction mixture was then cooled

Sources & evidence

ORD record
ord-680efd81620e40989b7f69bebfab4c81
Source dataset
uspto-grants-1981_04
Patent number
US04264600

Reaction notes

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