HuagongsheHuagongshe Chemistry Print Report · For research reference only
Epichlorohydrin → 2-Methoxy-3-(2-oxiranylmethoxy)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Methoxypyridin-3-ol | HCID 747009 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-Methoxy-3-(2-oxiranylmethoxy)pyridine | HCID 23463811 | — |
Reaction Steps
A mixture of 15.4 g of 3-hydroxy-2-methoxy-pyridine, 16 g of potassium carbonate, 25 ml of epichlorohydrin and 150 ml of acetonitrile is refluxed for 7 hours. Cooling and filtering the mixture and evaporating the filtrate yields crude 3-(2,3-epoxy-propoxy)-2-methoxypyridine, which is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04264599 |
| Source dataset | uspto-grants-1981_04 |
| ORD ID | ord-c074cd0e119b4961924d77d029f4aa8f |
| Source note | uspto-grants-1981_04 |