HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 1-{1-[2-Hydroxy-3-(2-nitro-3-pyridyloxy)-propyl]-4-piperidyl}-imidazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Pyridine, 2-nitro-3-(oxiranylmethoxy)-(9CI) | HCID 11183186 | — |
| Reactant | 1-(Piperidin-4-yl)imidazolidin-2-one | HCID 13031757 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1-{1-[2-Hydroxy-3-(2-nitro-3-pyridyloxy)-propyl]-4-piperidyl}-imidazolidin-2-one | HCID 23463796 | — |
Reaction Steps
A mixture of 46.0 g of 3-(2,3-epoxy-propoxy)-2-nitropyridine and 35.0 g of 1-(4-piperidyl)-imidazolidin-2-one in 500 ml of isopropanol is refluxed for 2 hours. Working up analogously to Example 1 using methylene chloride as the extracting agent yields crude 1-{1-[2-hydroxy-3-(2-nitro-3-pyridyloxy)-propyl]-4-piperidyl}-imidazolidin-2-one, which after recrystallisation from isopropanol melts at 154°-158°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04264599 |
| Source dataset | uspto-grants-1981_04 |
| ORD ID | ord-8c3f32fb951c4349a98e06e647d46c90 |
| Source note | uspto-grants-1981_04 |