HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malononitrile → [3,4'-BIPYRIDINE]-5-CARBONITRILE,6-METHOXY-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malononitrile | HCID 8010 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 3-Dimethylamino-2-(4-pyridinyl)acrolein | HCID 54197717 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | [3,4'-BIPYRIDINE]-5-CARBONITRILE,6-METHOXY- | HCID 13345674 | — |
Reaction Steps
A recently published abstract ["Current Abstracts of Chemistry", Vol. 74, Issue 814, Item 285573, 1979] of a Polish publication [Nantkanomirski and Kaczmarek, Polish J. Pharmacol. Pharmacy 30(5), 707-12 (1978)] shows, inter alia, the reaction of 3-dimethylamino-2-(4-pyridinyl)acrolein [same as β-(dimethylamino)-α-(4-pyridinyl)acrolein] with malononitrile in the presence of sodium methoxide in methanol to produce 2-methoxy-5-(4-pyridinyl)nicotinonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04264609 |
| Source dataset | uspto-grants-1981_04 |
| ORD ID | ord-84efa2c441514d7d895b3bee1b586c3e |
| Source note | uspto-grants-1981_04 |