HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 6-[(4-chlorophenyl)sulfanyl]-3-pyridinylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | p-Chlorothiophenol | HCID 7815 | — |
| Reactant | 2-Chloro-5-nitropyridine | HCID 78308 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-[(4-chlorophenyl)sulfanyl]-3-pyridinylamine | HCID 2800127 | — |
Reaction Steps
6-Chloro-3-nitropyridine (54.5 grams), 4-chlorothiophenol (50.0 grams), and lithium hydroxide (12.5 grams) were mixed in about 500 ml. of DMF and stirred overnight (about 18 hours) at room temperature. The reaction mixture was poured into ice-water, filtered, and the separated product washed three times with water and air dried, yield, 100 grams.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04264605 |
| Source dataset | uspto-grants-1981_04 |
| ORD ID | ord-f815efe19f0e4996899da64acd82ac39 |
| Source note | uspto-grants-1981_04 |