4-Amino-2-hydroxymethyl-3-methoxypyridine → HCID 178493894, compound

HRID 444502Notes

Reaction equation

HRID 444502 reaction equation
N[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][OH:9])[C:3]=1[O:10][CH3:11].N([O-])=[O:13].[Na+]>S(=O)(=O)(O)O>[OH:13][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][OH:9])[C:3]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 204742014-Amino-2-hydroxymethyl-3-methoxypyridineHCID 23668193Sodium Nitrite

Product 1

HCID 178493894HCID 178493894, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

4-Amino-2-hydroxymethyl-3-methoxypyridine is diazotised in dilute sulphuric acid with sodium nitrite and the diazonium compound is warmed to give 4-hydroxy-2-hydroxymethyl-3-methoxypyridine which may be demethylated with hydrobromic acid.

Sources & evidence

ORD record
ord-13577d9bfac84c0a9af168dc44a71764
Source dataset
uspto-grants-1981_04
Patent number
US04264608

Reaction notes

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