反应详情

With stirring, 1 g of pyridine in 3 ml of toluene and 2.3 g of α-cyclopropyl-4-chlorophenylacetyl chloride in 3 ml of toluene are added successively at 0° to 10° C. to a solution of 2.43 g of 3-(4-fluorophenoxy)-α-cyanobenzyl alcohol in 20 ml of toluene. After stirring for 10 hours at room temperature, the reaction mixture is washed with water, 2 N hydrochloric acid and 3% sodium bicarbonate solution. The organic layer is dried over sodium sulfate and the toluene is distilled off, affording the compound of the formula ##STR4## with a refractive index of nD20 =1.5880.

1. stirringAfter stirring for 10 hours at room temperature
2. washthe reaction mixture is washed with water, 2 N hydrochloric acid and 3% sodium bicarbonate solution
3. dry with materialThe organic layer is dried over sodium sulfate
4. distillationthe toluene is distilled off
5. customaffording the compound of the formula ##STR4## with a refractive index of nD20 =1.5880