HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → (S)-benzyl 2-(4-aminophenylcarbamoyl)pyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | (S)-benzyl 2-(4-(tert-butoxycarbonylamino)phenylcarbamoyl)pyrrolidine-1-carboxylate | HCID 59396122 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (S)-benzyl 2-(4-aminophenylcarbamoyl)pyrrolidine-1-carboxylate | HCID 59396116 | 94.7% |
Reaction Steps
To a solution of the Product from Example 3A (0.245 g, 0.56 mmol) in dioxane (5 mL) was added 4M HCl dioxane (2.8 mL, 11.2 mol) and the mixture was stirred at ambient temperature for 17 hours. The mixture was concentrated and azeotroped with toluene to give a tan solid (0.18 g, 86%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08541424B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-2fb70fcb6ee44d94841669e1f407e784 |
| Source note | uspto-grants-2013_09 |