HCID 54525609, compound → HCID 12874030, compound

HRID 444542Notes

Reaction equation

HRID 444542 reaction equation
[H][H].[C:3]([O:6][CH:7]=[CH:8][C:9]1([CH3:14])[NH:12][C:11](=[O:13])[CH2:10]1)(=[O:5])[CH3:4]>[Pd]>[C:3]([O:6][CH2:7][CH2:8][C:9]1([CH3:14])[NH:12][C:11](=[O:13])[CH2:10]1)(=[O:5])[CH3:4]

Participants

4

Reactant 2

HCID 54525609HCID 54525609, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 12874030HCID 12874030, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A solution of 4-(2-acetoxyvinyl)-4-methyl-2-azetidinone (10.0 g) 200 ml ethyl acetate containing 100 mg of 10% Pd/C is hydrogenated on a Parr shaker at 25° C. under 40 psi hydrogen for 15 minutes. The mixture is filtered through a bed of Supercel and washed with additional ethyl acetate. The combined filtrate is evaporated in vacuo to give 4-(2-acetoxyethyl)-4-methyl-2-azetidinone.

Workup

  1. filtrationThe mixture is filtered through a bed of Supercel
  2. washwashed with additional ethyl acetate
  3. customThe combined filtrate is evaporated in vacuo

Sources & evidence

ORD record
ord-4bac266903324bdd81a5d24084c5eced
Source dataset
uspto-grants-1981_04
Patent number
US04264621

Reaction notes

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