Sodium Bicarbonate → HCID 178482019, compound

Participants

Reaction Steps

In a solution of 0.168 g of sodium hydrogen carbonate in 4 ml of water was dissolved 0.578 g of 7-[2-(2-imino-4-thiazolin-4-yl)-2-hydroxyimino-acetamido]-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid hydrobromide. The solution was subjected to column chromatography on dextran gel (Sephadex LH-20, Pharmacia), development being carried out with water. The fractions including the desired product were pooled and lyophilized. By the above procedure there was obtained 0.267 g of the captioned compound.

Provenance & Evidence