Sodium Bicarbonate → HCID 178475888, compound

Participants

Reaction Steps

In 20 m of water there was suspended 0.525 g of 7-[2-(2-amidinothioacetylimino-4-thiazolin-4-yl)-2-acetoxyimino-acetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid hydrochloride (syn-isomer), followed by the addition of 0.252 g of sodium hydrogen carbonate. The mixture was stirred at room temperature for 15 hours. The reaction mixture, as such, was subjected to column chromatography on polystyrene resin (Amberlite XAD-2, Rohm and Haas Co.) and the fractions containing the desired product were pooled and lyophilized.

Provenance & Evidence