反应详情

In 30 ml of acetic acid there were dissolved 6.94 g of benzhydryl 4-bromo-3-oxobutyrate and, under ice-cooling and stirring, a solution of 1.588 g of sodium nitrite in 6 ml of water was added dropwise. The mixture was further stirred at that temperature for 20 minutes and, following addition of 60 ml of a saturated aqueous solution of sodium chloride, the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with a saturated aqueous solution of sodium chloride and dried over magnesium sulfate. The solvent was removed under reduced pressure to recover 7.56 g of the captioned compound.

1. temperatureunder ice-cooling
2. stirringThe mixture was further stirred at that temperature for 20 minutes
3. extractionthe mixture was extracted with ethyl acetate
4. washThe ethyl acetate layer was washed with a saturated aqueous solution of sodium chloride
5. dry with materialdried over magnesium sulfate
6. customThe solvent was removed under reduced pressure
7. customto recover 7.56 g of the captioned compound