Methyl iodide → Ethyl 3-methylamino-4-cyclohexylphenylglyoxylate

HRID 444564Notes

Reaction equation

HRID 444564 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:14](=[O:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.[CH3:21]I>N1C=CC=CC=1>[CH3:21][NH:1][C:2]1[CH:3]=[C:4]([C:14](=[O:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 20515218Ethyl 3-amino-4-cyclohexylphenylglyoxylate

Product 1

HCID 20515175Ethyl 3-methylamino-4-cyclohexylphenylglyoxylate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 0.01 moles of ethyl 3-amino-4-cyclohexylphenylglyoxylate in 100 ml. of pyridine is added 0.1 moles of methyl iodide. The reaction mixture is stirred overnight at room temperature, filtered and concentrated. The residue is distilled to obtain ethyl 3-methylamino-4-cyclohexylphenylglyoxylate.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated
  3. distillationThe residue is distilled

Sources & evidence

ORD record
ord-4dfc259075f5434f8bc2e25b2da60f38
Source dataset
uspto-grants-1981_04
Patent number
US04264627

Reaction notes

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