HCID 58049711, compound → HCID 58049706, compound

HRID 444606Notes

Reaction equation

HRID 444606 reaction equation
[C:1]1([C:7]2[NH:8][C:9]3[C:10]4[N:58]=[C:57]([C:59]5[CH:64]=[CH:63][CH:62]=[CH:61][CH:60]=5)[CH:56]=[C:55]([C:65]5[CH:70]=[CH:69][CH:68]=[CH:67][CH:66]=5)[C:11]=4[CH2:12][CH2:13][C:14]=3[CH:15]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([CH:23]4[C:32]5[CH2:31][CH2:30][C:29]6[C:33]([C:43]7[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=7)=[CH:34][C:35]([C:37]7[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=7)=[N:36][C:28]=6[C:27]=5[NH:26][C:25]([C:49]5[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=5)=[N:24]4)[CH:18]=3)[N:16]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[Pd].C(O)COCCO>[C:49]1([C:25]2[N:24]=[C:23]([C:19]3[CH:20]=[CH:21][CH:22]=[C:17]([C:15]4[C:14]5[C:9](=[C:10]6[N:58]=[C:57]([C:59]7[CH:64]=[CH:63][CH:62]=[CH:61][CH:60]=7)[CH:56]=[C:55]([C:65]7[CH:70]=[CH:69][CH:68]=[CH:67][CH:66]=7)[C:11]6=[CH:12][CH:13]=5)[N:8]=[C:7]([C:1]5[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=5)[N:16]=4)[CH:18]=3)[C:32]3[C:27](=[C:28]4[N:36]=[C:35]([C:37]5[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=5)[CH:34]=[C:33]([C:43]5[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=5)[C:29]4=[CH:30][CH:31]=3)[N:26]=2)[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=1

Participants

4

Reactant 1

HCID 58049711HCID 58049711, compound

Product 1

HCID 58049706HCID 58049706, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8117Diethylene GlycolSolvent

Procedure

A suspension of 1,3-bis(2,7,9-triphenyl-1,4,5,6-tetrahydropyrido[3,2-h]quinazolin-4-yl)benzene (5) (4.4 mmol) in 220 diethyleneglycol was heated until total dissolution. 1.2 g Pd/C was then slowly added, and the reaction was refluxed for 6 hours with argon bubbling directly in the solution. The reaction was then stopped, and the suspension cooled to room temperature.

Workup

  1. temperaturewas heated until total dissolution
  2. temperaturethe reaction was refluxed for 6 hours with argon bubbling directly in the solution

Sources & evidence

ORD record
ord-4352c6a372534f1d85c587f7a1676115
Source dataset
uspto-grants-2013_07
Patent number
US08475686B2

Reaction notes

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