참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzaldehyde | HCID 240 | — |
| 반응물 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | tert-Butyl 4-aminocyclohexane-1-carboxylate | HCID 18698345 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Benzylamino-cyclohexanecarboxylic acid tert-butyl ester | HCID 68724841 | 100.9% |
반응 단계
To a solution of 4-amino-cyclohexanecarboxylic acid tert-butyl ester (500 mg, 2.500 mmol) in MeOH (3 mL) is added TEA (140 uL, 1.000 mmol), MgSO4 (452 mg, 3.750 mmol), and benzaldehyde (278 uL, 2.750 mmol). The mixture stirs 1 h. The mixture is then cooled to 0° C. and NaBH4 (568 mg, 15.00 mmol) is added portionwise over 10 min. The mixture stirs 1 h at ambient temperature. Then H2O (20 mL) is added and the mixture is extracted with EtOAc (2×50 mL), dried and concentrated to affords 730 mg of 4-benzylamino-cyclohexanecarboxylic acid tert-butyl ester. LC/MS: [M+H]+ 290, Rt=0.80 min (method 6).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08476224B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_07 |
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| ORD ID | ord-5e9039f2f12d4e88a6cb87c4b568f737 |
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| 출처 메모 | uspto-grants-2013_07 |
|---|
