HCID 58134770, compound → 1-Amino-1-(2-hydroxypropan-1-yl)cyclobutane

HRID 444780Notes

Reaction equation

HRID 444780 reaction equation
C([NH:8][C:9]1([CH2:13][CH:14]([OH:16])[CH3:15])[CH2:12][CH2:11][CH2:10]1)C1C=CC=CC=1>CCO.[Pd]>[NH2:8][C:9]1([CH2:13][CH:14]([OH:16])[CH3:15])[CH2:12][CH2:11][CH2:10]1

Participants

4

Reactant 1

HCID 58134770HCID 58134770, compound

Product 1

HCID 552844011-Amino-1-(2-hydroxypropan-1-yl)cyclobutaneYield 94.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10% Pd—C (300 mg) was added to a solution of 1-[1-(benzylamino)cyclobutyl]-2-propanol (2.24 g, 10.2 mmol) in EtOH (50 mL) and the mixture was stirred under H2 gas (5 kgf/cm2) at room temperature for 10 hours. The mixture was filtered and the filtrate was concentrated in vacuo. Distillation of the residue gave the title compound as a pale yellow oil (1.24 g, 94%).

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo
  3. distillationDistillation of the residue

Sources & evidence

ORD record
ord-93fdf6017015460699d920979f2556f5
Source dataset
uspto-grants-2013_07
Patent number
US08476261B2

Reaction notes

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