Acetic Anhydride → HCID 178471963, compound

Participants

Reaction Steps

A stirred solution of ethyl 3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate (10.0 g, 37.8 mmol), acetic anhydride (50 mL) and triethyl orthoformate (10.0 mL, 56.7 mmol) was heated at 130° C. for 3 h. The mixture was concentrated and dried under high vacuum for 5 hours. The crude product was dissolved in DCM (50 mL) and then 1-amino-1-cyclopropylmethanol (3.9 g, 45.3 mmol) was added dropwise at room temperature. After 1.5 h, the solvent was removed by evaporation to yield the title compound as a yellow solid (9 g) that was used in the next step without further purification. MS (EP) m/z: 362 (M++1). (Calcd. For C16H15F4NO4, 361.29)

Provenance & Evidence