Dimethylformamide → HCID 14146225, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 3-(1-(hydroxymethyl)cyclopropylamino)-2-(2,3,4,5-tetrafluoro-benzoyl)acrylate (300 mg, 0.83 mmol), K2CO3 powder (344 mg, 2.49 mmol), and 3 ml of anhydrous DMF were heated in a CEM Discover microwave for 10 min at 200° C. After that the sample was rapidly cooled to room temperature yielding a dark brown liquid. The DMF was removed by evaporation to give a dark solid. The solid was dissolved in 50 ml of ethylacetate and washed two times with 10 ml of water. The organic layer was dried over Na2SO4 to afford a light yellow solid as the title compound which was used without further purification in the next step (133 mg, 0.415 mmol). MS (EP) m/z: 322 (M++1). (Calcd. for C16H13F2NO4, 321.28)

Provenance & Evidence