HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 444870Generated: October 25, 2026
tert-butyl N-(4-methyl-1,3-thiazol-2-yl)carbamate → {5-[2-(1-Cyano-cyclobutyl)-pyridin-4-yl]-4-methyl-thiazol-2-yl}-carbamic acid tert-butyl ester
https://huagongshe.com/reaction/444870
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-butyl N-(4-methyl-1,3-thiazol-2-yl)carbamate | HCID 45117839 | — |
| Reactant | 1-(4-Bromopyridin-2-yl)cyclobutane-1-carbonitrile | HCID 57417094 | — |
| Product | {5-[2-(1-Cyano-cyclobutyl)-pyridin-4-yl]-4-methyl-thiazol-2-yl}-carbamic acid tert-butyl ester | HCID 59293719 | — |
Reaction Steps
The title compound is prepared in analogy to the procedure described in Step 1.3, but using 1-(4-bromo-pyridin-2-yl)-cyclobutanecarbonitrile (Step 19.3) and (4-methyl-thiazol-2-yl)-carbamic acid tert-butyl ester (Step 18.4). The reaction mixture is stirred for 3 h at 100° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08476268B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-efd0985854274ea396ff2eee46fe08df |
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| Source note | uspto-grants-2013_07 |
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