HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 444874Generated: October 27, 2026
tert-butyl N-(4-methyl-1,3-thiazol-2-yl)carbamate → Tert-butyl 5-(2-(2-cyanopropan-2-yl)pyridin-4-yl)-4-methylthiazol-2-ylcarbamate
https://huagongshe.com/reaction/444874
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-butyl N-(4-methyl-1,3-thiazol-2-yl)carbamate | HCID 45117839 | — |
| Reactant | 2-(4-Iodopyridin-2-yl)-2-methylpropanenitrile | HCID 59293717 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Tert-butyl 5-(2-(2-cyanopropan-2-yl)pyridin-4-yl)-4-methylthiazol-2-ylcarbamate | HCID 59293723 | — |
Reaction Steps
The title compound is prepared in analogy to the procedure described in Step 1.3, but using 2-(4-iodo-pyridin-2-yl)-2-methyl-propionitrile (Step 21.5) and (4-methyl-thiazol-2-yl)-carbamic acid tert-butyl ester (Step 18.4). The reaction mixture is stirred for 3 h at 100° C. Title compound: ESI-MS: 359.1 [M+H]+; TLC: Rf=0.47 (Hex/EtOAc, 1:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08476268B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-d6916f8695cb47b785e052b8ce215726 |
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| Source note | uspto-grants-2013_07 |
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