3-Amino-1,1,1-trifluoropropan-2-ol → 3-(2,5-Dimethyl-pyrrol-1-yl)-6-methoxy-5-trifluoromethyl-pyridine-2-carboxylic acid (3,3,3-trifluoro-2-hydroxy-propyl)-amide

HRID 444906Notes

Reaction equation

HRID 444906 reaction equation
[CH3:1][C:2]1[N:3]([C:8]2[C:9]([C:20]([OH:22])=O)=[N:10][C:11]([O:18][CH3:19])=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:13]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[NH2:23][CH2:24][CH:25]([OH:30])[C:26]([F:29])([F:28])[F:27]>>[F:27][C:26]([F:29])([F:28])[CH:25]([OH:30])[CH2:24][NH:23][C:20]([C:9]1[C:8]([N:3]2[C:4]([CH3:7])=[CH:5][CH:6]=[C:2]2[CH3:1])=[CH:13][C:12]([C:14]([F:17])([F:15])[F:16])=[C:11]([O:18][CH3:19])[N:10]=1)=[O:22]

Participants

3

Reactant 2

HCID 4189653-Amino-1,1,1-trifluoropropan-2-olHCID 584423133-(2,5-Dimethyl-pyrrol-1-yl)-6-methoxy-5-trifluoromethyl-pyridine-2-carboxylic acid2×

Product 1

HCID 866576653-(2,5-Dimethyl-pyrrol-1-yl)-6-methoxy-5-trifluoromethyl-pyridine-2-carboxylic acid (3,3,3-trifluoro-2-hydroxy-propyl)-amide

Procedure

This compound was prepared from 3-(2,5-Dimethyl-pyrrol-1-yl)-6-methoxy-5-trifluoromethyl-pyridine-2-carboxylic acid (Intermediate D2) and 3-amino-1,1,1-trifluoropropan-2-ol analogously to Example 1; LC-MS Rt=1.50 mins [M+H]+ 426 (Method 2 minLC_v002).

Sources & evidence

ORD record
ord-548e593131b241c9b1f68136f8a2e597
Source dataset
uspto-grants-2013_07
Patent number
US08476269B2

Reaction notes

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