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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 444947Generated: October 25, 2026

Methyl 3-amino-6-(oxazol-2-yl)-5-(trifluoromethyl)picolinate → 3-Amino-6-furan-2-yl-5-trifluoromethyl-pyrazine-2-carboxylic acid

https://huagongshe.com/reaction/444947

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 3-amino-6-(oxazol-2-yl)-5-(trifluoromethyl)picolinateHCID 67383553—
ReactantEthyl 3-amino-6-bromo-5-(trifluoromethyl)pyrazine-2-carboxylateHCID 72942096—
ReactantTributyltin 2-furylstannaneHCID 131729901—
Product3-Amino-6-furan-2-yl-5-trifluoromethyl-pyrazine-2-carboxylic acidHCID 58442354—

Reaction Steps

The title compound was prepared from 3-amino-6-bromo-5-trifluoromethyl-pyrazine-2-carboxylic acid ethyl ester (Intermediate C1) and tributyltin-2-furylstannane analogously to methyl 3-amino-6-(oxazol-2-yl)-5-(trifluoromethyl)picolinate (Intermediate P)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08476269B2
Source datasetuspto-grants-2013_07
ORD IDord-ca40dec7a06546d2b4148fc34d9a5674
Source noteuspto-grants-2013_07