Hydrazine → 3,3,3-Trifluoro-2-methoxy-2-methylpropan-1-amine

HRID 444955Notes

Reaction equation

HRID 444955 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]([O:17][CH3:18])([CH3:16])[CH2:4][N:5]1C(=O)C2C(=CC=CC=2)C1=O.NN>>[F:1][C:2]([F:20])([F:19])[C:3]([O:17][CH3:18])([CH3:16])[CH2:4][NH2:5]

Participants

3

Reactant 2

HCID 9321HydrazineHCID 67383555HCID 67383555, compound

Product 1

HCID 584423513,3,3-Trifluoro-2-methoxy-2-methylpropan-1-amine

Procedure

A mixture comprising 2-(3,3,3-trifluoro-2-methoxy-2-methylpropyl)isoindoline-1,3-dione (272 mg, 0.95 mmol) and hydrazine (0.033 ml, 1.045 mmol) was stirred at 75° C. for 4 hours. After cooling to RT, the mixture was filtered and the filtrate was concentrated in vacuo to afford the title product which was used without further purification (no characterisation data available).

Workup

  1. filtrationthe mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-e842e1713d324ba68beff61f76e89a1d
Source dataset
uspto-grants-2013_07
Patent number
US08476269B2

Reaction notes

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