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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 445067Generated: October 30, 2026

1-(2-Chloroethyl)-2,4-difluorobenzene → 9-[2-(2,4-Difluoro-phenyl)-ethyl]-8-(2,5-dimethoxy-phenylsulfanyl)-9H-purine-6-ylamine

https://huagongshe.com/reaction/445067

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Chloroethyl)-2,4-difluorobenzeneHCID 54554924—
ReactantHCID 178492621HCID 178492621—
Product9-[2-(2,4-Difluoro-phenyl)-ethyl]-8-(2,5-dimethoxy-phenylsulfanyl)-9H-purine-6-ylamineHCID 57850820—

Reaction Steps

The title compound was prepared from 8-(2,5-dimethoxy-phenylsulfanyl)-9H-purin-6-ylamine and 1-(2-chloro-ethyl)-2,4-difluoro-benzene by a procedure similar to examples 1 and 2. The compound was purified by preparative HPLC. LC-MS [M+H]+ 444.1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08476285B2
Source datasetuspto-grants-2013_07
ORD IDord-78c29234b820496c881c535ffcb481c2
Source noteuspto-grants-2013_07