Thionyl Chloride → HCID 22568265, compound

HRID 445077Notes

Reaction equation

HRID 445077 reaction equation
[CH2:1]([N:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH:5]1[CH2:10][CH2:11]O)[CH2:2][CH3:3].S(Cl)([Cl:15])=O>ClCCl>[Cl:15][CH2:11][CH2:10][CH:5]1[CH2:6][CH2:7][CH2:8][CH2:9][N:4]1[CH2:1][CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 21153799HCID 21153799, compound

Product 1

HCID 22568265HCID 22568265, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-(1-propyl-piperidin-2-yl)-ethanol (0.150 g, 0.875 mmol) in dichloromethane (5 mL) was added thionyl chloride (1.0 mL, 13.70 mmol) at room temperature and the reaction mixture was refluxed for 3 h. The solvent and excess thionyl chloride was removed under reduced pressure. The product was dissolved in dichloromethane and evaporated to dryness. The product was used for the next step without further purifications. GC-MS m/z 189.00.

Workup

  1. temperaturethe reaction mixture was refluxed for 3 h
  2. customThe solvent and excess thionyl chloride was removed under reduced pressure
  3. dissolutionThe product was dissolved in dichloromethane
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-f9e25ddc82fa441d92238b0e1d692b03
Source dataset
uspto-grants-2013_07
Patent number
US08476285B2

Reaction notes

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