Ethyl isothiocyanate → HCID 57850772, compound

Participants

Reaction Steps

To a solution of 2-(piperidin-4-yl)ethanol (509 mg, 3.94 mmol) in CH2Cl2 (13 mL) was added isothiocyanatoethane (343 μL, 3.94 mmol). After stirring for 10 h at rt, the mixture was concentrated in vacuo to provide the titled compound (716 mg, 84%): 1H NMR (CDCl3) δ 5.38 (brs, 1H), 4.59 (d, J=13.6 Hz, 1H), 3.74-3.67 (m, 3H), 3.15 (d, J=12.8 Hz, 1H), 3.00 (t, J=13.2 Hz, 2H), 2.65 (t, J=12.4 Hz, 1H), 1.81-1.72 (m, 3H), 1.55-1.52 (m, 3H), 1.28-1.22 (m, 4H)

Provenance & Evidence