HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl {(1S)-2-[4-(2-{6-amino-8-[(7-chloro-1,3-benzothiazol-2-yl)thio]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-methyl-2-oxoethyl}carbamate | HCID 57850166 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Trifluoroacetate | HCID 84468 | — |
| Product | 9-(2-{1-[(2S)-2-Aminopropanoyl]piperidin-4-yl}ethyl)-8-[(7-chloro-1,3-benzothiazol-2-yl)thio]-9H-purin-6-amine | HCID 57850333 | — |
Reaction Steps
To a solution of Boc protected product from example 773 in DCM was added TFA and stirred at room temperature for 3 h. The solvent and excess TFA was evaporated under reduced pressure and the residual TFA was removed by co-evaporating with toluene to give title product as trifluoroacetate salt. 1H NMR δ (CD3OD), 8.35 (s, 1H), 7.84-7.82 (m, 1H), 7.50-7.40 (m, 2H), 4.40 (t, J=7.2 Hz, 2H), 4.00-3.90 (m, 1H), 1.80-1.70 (m, 4H), 1.41-1.37 (m, 4H), 1.32-1.30 (m, 3H), 1.20 (s, 3H); LC-MS [M+H]+ 517.1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476285B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-5ccc15c84e7a4312be4464feec668db9 |
| Source note | uspto-grants-2013_07 |