Carbon tetrabromide → HCID 67972772, compound

Participants

Reaction Steps

[3-[2,4-dimethyl-6-(3-methylsulfonylpropoxy)pyridin-3-yl]phenyl]methanol (0.30 g) synthesized according to the methods in (Reference Example 5) and (Example 11) <Step 2> and carbon tetrabromide (0.34 g) were dissolved in methylene chloride (1.8 mL) and to the resultant solution, a solution of triphenylphosphine (0.34 g) in methylene chloride (0.9 mL) was added, followed by stirring the resultant reaction mixture at room temperature for 3 hours. From the reaction mixture, the solvent was distilled off under reduced pressure, and the resultant residue was purified by silica gel column chromatography (eluate; n-hexane:ethyl acetate=3:2) to obtain the subject compound (0.21 g) as a colorless liquid.

Provenance & Evidence