HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Benzyl-2-azabicyclo[2.2.1]heptan-7-one → 4-(4-((1SR,4SR,7RS)-2-azabicyclo[2.2.1]heptan-7-ylamino)phenyl)-1,2,5-oxadiazol-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Benzyl-2-azabicyclo[2.2.1]heptan-7-one | HCID 49759181 | — |
| Reactant | HCID 59799786 | HCID 59799786 | — |
| Product | 4-(4-((1SR,4SR,7RS)-2-azabicyclo[2.2.1]heptan-7-ylamino)phenyl)-1,2,5-oxadiazol-3-amine | HCID 67235677 | — |
Reaction Steps
Reaction of 4-(4-aminophenyl)-1,2,5-oxadiazol-3-amine with 2-benzyl-2-azabicyclo[2.2.1]heptan-7-one (J. R. Malpass, S. Handa, and R. White, Org. Lett., 2005, 7, 2759-2762) affords the title compound as the benzyl-protected amine. Purification by chromatography followed by removal of the benzyl group by hydrogenolysis affords the title amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476295B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-48b87bafb6304292a8b2b30dd86d2c5e |
| Source note | uspto-grants-2013_07 |