HCID 11438127, compound → HCID 11370811, compound

HRID 445147Notes

Reaction equation

HRID 445147 reaction equation
Cl[C:2]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([CH:12]([CH3:14])[CH3:13])=[CH:8][CH:7]=1)=[O:5]>C(N)(C)C>[CH:16]([NH:19][C:2]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([CH:12]([CH3:14])[CH3:13])=[CH:8][CH:7]=1)=[O:5])([CH3:17])[CH3:15]

Participants

3

Reactant 1

HCID 11438127HCID 11438127, compound

Product 1

HCID 11370811HCID 11370811, compound

Reagents, catalysts & solvents 1

HCID 6363IsopropylamineSolvent

Conditions

Temperature
65 °C

Procedure

A mixture of 300 mg (0.95 mmol) of the compound obtained in step B in 15 ml isopropylamine is heated to 65° C. for 10 h in a sealed tube. The excess of amine is stripped off i.v. Extraction of the residue with ethyl acetate/water gives a quantitative yield of the product in form of a yellow resin, which is used without purification in the next step.

Workup

  1. extractionExtraction of the residue with ethyl acetate/water

Sources & evidence

ORD record
ord-cb53587fbf9149d7b2e8490eee5b3b7e
Source dataset
uspto-grants-2013_07
Patent number
US08476286B2

Reaction notes

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