Potassium Carbonate → (4-Isopropyl-phenyl)-{5-methoxy-2-[(pyridin-2-ylmethyl)-amino]-phenyl}-methanone

Participants

Reaction Conditions

Reaction Steps

410 mg (2.97 mmol) potassium carbonate and 150 mg (0.59 mmol) 2-bromoethylpyridine hydrobromide are added to a solution of 160 mg (0.59 mmol) (2-amino-5-methoxy-phenyl)-(4-isopropyl-phenyl)-methanone in 3 ml acetone. The reaction mixture is stirred for 2 days at 90° C., diluted with ethyl acetate and extracted with brine. The organic layer is dried and evaporated. After chromatography (hexane/ethyl acetate) the product is obtained as yellow oil.

Provenance & Evidence