HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → HCID 59259087, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Propargyl bromide | HCID 7842 | — |
| Reactant | 5-Hydroxy-2-nitrobenzaldehyde | HCID 39211 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 59259087 | HCID 59259087 | — |
Reaction Steps
A mixture of 25 g (150 mmol) 5-hydroxy-2-nitro-benzaldehyde, 44.9 g (299 mmol) sodium iodide, 44.5 g propargyl bromide (80% in toluene), 42 ml N-ethyl-diisopropylamine and 400 ml acetone is stirred at rt for 6 d. The reaction mixture is filtered, concentrated, taken up in 1M aqueous hydrochloric acid and extracted with ethyl acetate to yield 2-nitro-5-propargyloxy-benzaldehyde.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476286B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-35de5a1b7a684471af5836153f19aa44 |
| Source note | uspto-grants-2013_07 |