HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → (2-Benzylamino-5-propargyloxy-phenyl)-(4-isopropyl-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (2-Amino-5-(prop-2-yn-1-yloxy)phenyl)(4-isopropylphenyl)methanone | HCID 45139628 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (2-Benzylamino-5-propargyloxy-phenyl)-(4-isopropyl-phenyl)-methanone | HCID 45140213 | — |
Reaction Steps
A solution of 100 mg (0.341 mmol) (2-amino-5-propargyloxy-phenyl)-(4-isopropyl-phenyl)-methanone, 44.6 μl (0.375 mmol) benzyl bromide and 32 μl (0.375 mmol) N-ethyl-diisopropylamine in 2 ml dioxane is heated at 100° for 90 h. The reaction mixture is concentrated and the residue taken up in 0.1 M sodium hydroxide solution and extracted with dichloromethane. Preparative HPLC affords (2-benzylamino-5-propargyloxy-phenyl)-(4-isopropyl-phenyl)-methanone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476286B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-867c9a83e870470094a67110dba800cf |
| Source note | uspto-grants-2013_07 |