反应详情

To a solution of 482 mg (1.13 mmol) 1-(2-hydroxy-benzyl)-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one in 2 ml dichloromethane is added 1 ml 1M aqueous NaOH. After stirring for 5 minutes the solvents are evaporated. The residue is dissolved in 4.8 ml DMEU and 0.25 ml (1.70 mmol) 1-bromo-6-chlorohexane are added. After stirring for 3 days at rt additional 0.083 ml 1-bromo-6-chlorohexane are added and stirring at rt is continued for 1 day. The reaction mixture is poured onto water, extracted with ethyl acetate and purified by flash chromatography (hexanes/ethyl acetate 6:1).

1. customare evaporated
2. dissolutionThe residue is dissolved in 4.8 ml DMEU
3. additionare added
4. stirringstirring at rt
5. waitis continued for 1 day
6. additionThe reaction mixture is poured onto water
7. extractionextracted with ethyl acetate
8. custompurified by flash chromatography (hexanes/ethyl acetate 6:1)